Utilizing Carbonyl-Coordination of Native Amides for Pd– catalyzed C(sp3)–H Olefination

Autor:	Yang Li, Hojoon Park, Jin-Quan Yu
Rok vydání:	2019
Předmět:	chemistry.chemical_compound Chemistry Ligand Stereochemistry Amide Moiety Catalysis
Popis:	Pd(II)–catalyzed C(sp3)–H olefination of native amide substrates was developed. To utilize the extremely weak-coordinating carbonyl-coordination of amides, an electron-deficient pyridinesulfonic acid ligand was designed. Structurally diverse amide substrates, including lactams, underwent olefination without the undesired cyclization. Olefination products were further diversified through synthetic transformations on the alkenyl moiety.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f228976a3307738ae877ec4518358cf https://doi.org/10.26434/chemrxiv.8135534.v1 Zobrazit plný text záznamu