Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms
| Autor: | Moacir Wajner, J. De Bastiani, R. E. Jimenez-Bernal, Maribel Antonello Rubin, E. J. M. Da Costa, J. Begnini, C. F. de Mello |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Microinjections Rotation Methylmalonic acid Excitotoxicity Glutamic Acid Striatum medicine.disease_cause chemistry.chemical_compound Seizures Internal medicine Convulsion medicine Animals Rats Wistar Molecular Biology General Neuroscience Neurotoxicity Glutamate receptor food and beverages medicine.disease Rats Neostriatum Succinate Dehydrogenase Endocrinology chemistry Methylmalonic aciduria Anesthesia NMDA receptor Indicators and Reagents Neurology (clinical) Dizocilpine Maleate Stereotyped Behavior medicine.symptom Excitatory Amino Acid Antagonists Methylmalonic Acid Developmental Biology |
| Zdroj: | Brain Research. 721:120-125 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(96)00117-5 |
| Popis: | The effect of intrastriatal administration of methylmalonic acid (MMA), a metabolite that accumulates in methylmalonic aciduria, on behavior of adult male Wistar rats was investigated. After cannula placing, rats received unilateral intrastriatal injections of MMA (buffered to pH 7.4 with NaOH) or NaCl. MMA induced rotational behavior toward the contralateral side of injection and clonic convulsions in a dose-dependent manner. Rotational behavior and convulsions were prevented by intrastriatal preadministration of MK-801 and attenuated by preadministration of succinate. This study provides evidence for a participation of NMDA receptors in the MMA-induced behavioral alterations, where succinate dehydrogenase inhibition seems to have a pivotal role. |
| Databáze: | OpenAIRE |
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