Prevalence of β-Lactamases among 1,072 Clinical Strains of Proteus mirabilis : a 2-Year Survey in a French Hospital
| Autor: | D. Sirot, Richard Bonnet, Catherine Chanal, Roger Labia, C. De Champs, Jacques Sirot |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.drug_class
Penicillin Resistance Antibiotics Microbial Sensitivity Tests Penicillins Drug resistance beta-Lactam Resistance beta-Lactamases Microbiology Gene Frequency Mechanisms of Resistance medicine Humans Pharmacology (medical) Hospitals Teaching Proteus mirabilis Antibacterial agent Pharmacology biology β lactamases Amoxicillin Penicillinase biology.organism_classification Enterobacteriaceae Phenotype Infectious Diseases France beta-Lactamase Inhibitors Bacteria medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 44:1930-1935 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.44.7.1930-1935.2000 |
| Popis: | β-Lactam resistance was studied in 1,072 consecutive P. mirabilis clinical strains isolated at the Clermont-Ferrand teaching hospital between April 1996 and March 1998. The frequency of amoxicillin resistance was 48.5%. Among the 520 amoxicillin-resistant isolates, three resistance phenotypes were detected: penicillinase (407 strains [78.3%]), extended-spectrum β-lactamase (74 strains [14.2%]), and inhibitor resistance (39 strains [7.5%]). The penicillinase phenotype isolates were divided into three groups according to the level of resistance to β-lactams, which was shown to be related to the strength of the promoter. The characterization of the different β-lactamases showed that amoxicillin resistance in P. mirabilis was almost always (97%) associated with TEM or TEM-derived β-lactamases, most of which evolved via TEM-2. |
| Databáze: | OpenAIRE |
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