Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: A case report with a long term follow-up
| Autor: | Gladys Smok, Sebastián Valderrama, Rosa María Pérez-Ayuso, Bruno Nervi, Marco Arrese, Juan Carlos Rodriguez, Alvaro Koch, Danny Oksenberg, Alejandro Soza, Ignacio Duarte, Nicolás Jarufe, Jorge Martínez, Arnoldo Riquelme, Felipe Salech |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Abdominal pain medicine.medical_specialty Lung Neoplasms Time Factors Hepatic tumors Long term follow up Biopsy Fine-Needle Specialties of internal medicine Angiogenesis Inhibitors Hepatic Epithelioid Hemangioendothelioma medicine Humans Hepatology medicine.diagnostic_test business.industry Liver Neoplasms Disease progression Anti-angiogenic therapy General Medicine Malignant Vascular Tumor Abdominal Pain Thalidomide Surgery Treatment Outcome RC581-951 Endothelial tumors Liver biopsy Toxicity Hemangioendothelioma Epithelioid Female medicine.symptom Tomography X-Ray Computed business Hepatomegaly medicine.drug |
| Zdroj: | Annals of Hepatology, Vol 10, Iss 1, Pp 99-102 (2011) |
| ISSN: | 1665-2681 |
| DOI: | 10.1016/s1665-2681(19)31596-0 |
| Popis: | Hepatic epithelioid hemangioendothelioma (HEH) is an unusual, low-grade malignant vascular tumor of the liver. Here we describe a case of a 40-year-old woman who presented with abdominal pain in the upper right quadrant and giant hepatomegaly, in which imaging studies and a fine-needle liver biopsy confirmed the presence of a large EHE with an isolated lung metastasis. After balancing all possible therapeutic modalities the patient was treated conservatively with thalidomide (300 mg/day). The drug was well tolerated with minimal toxicity and the patient continues on therapy 109 months after treatment was started with no disease progression. Current therapeutic options for HEH are discussed in light of the clinical case with particular emphasis on anti-angiogenic therapies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|