Innovations, challenges, and minimal information for standardization of humanized mice

Autor: Michael A. Brehm, Carol J. Bult, Johannes Sam, Florian Klein, Silvia Guionaud, Karl-Dimiter Bissig, James P. Di Santo, Anja Kathrin Wege, Terrence Meeham, Dominique Bonnet, Scott G. Kitchen, Livio Trusolino, Kourosh Saeb-Parsy, Christian Münz, Brian Soper, Kristina E. Howard, Amar Deep Sharma, Renata Stripecke, Estefanía Rodríguez, Leonard D. Shultz, Li-Chin Yao, Andreas Trumpp, Jan Jacob Schuringa
Přispěvatelé: University of Zurich, Stripecke, Renata, Stripecke, Renata [0000-0001-7756-8460], Münz, Christian [0000-0001-6419-1940], Schuringa, Jan Jacob [0000-0001-8452-8555], Trumpp, Andreas [0000-0002-6212-3466], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Medicine (General)
Standardization
HEPATITIS-B
Review
Mice
SCID
QH426-470
10263 Institute of Experimental Immunology
Regenerative medicine
Chromatin
Epigenetics
Genomics & Functional Genomics
immuno‐oncology
Mice
0302 clinical medicine
Neoplasms
Medicine
infections
LIVER CHIMERIC MICE
BREAST-CANCER CELLS
MOUSE MODEL
humanized mice
Molecular Medicine
Heterografts
Immunology
regenerative medicine
Context (language use)
610 Medicine & health
Guidelines as Topic
VIRUS-INFECTION
Computational biology
03 medical and health sciences
R5-920
Genetics
XENOGRAFTS
immuno-oncology
PDX
Animals
Humans
HEMATOPOIETIC STEM-CELLS
business.industry
Reproducibility of Results
Disease Models
Animal
HUMAN HEPATOCYTES
030104 developmental biology
1313 Molecular Medicine
Humanized mouse
570 Life sciences
biology
IMMUNE-SYSTEM
Breast cancer cells
Antibody therapy
business
030217 neurology & neurosurgery
ANTIBODY THERAPY
Zdroj: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
ISSN: 1757-4684
1757-4676
Popis: Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human‐specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community‐driven resource called “Minimal Information for Standardization of Humanized Mice” (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. Within MISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.
Humanized mice are at the forefront of biomedical research and becoming more mainstream preclinical models. This comprehensive review talks about innovations and challenges regarding the reconstitution of human immunity and introduces “Minimal Information for Standardization of Humanized Mice” (MISHUM).
Databáze: OpenAIRE
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