Breast cancer genetics: What we know and what we need
| Autor: | K L, Nathanson, R, Wooster, B L, Weber, K N, Nathanson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
BRCA2 Protein
Genetics Incidence (epidemiology) Genes BRCA1 Breast Neoplasms General Medicine Biology medicine.disease Bioinformatics General Biochemistry Genetics and Molecular Biology Neoplasm Proteins Germline mutation Breast cancer medicine Genetic predisposition Humans Female Genetic Predisposition to Disease Allele Breast Cancer Genetics skin and connective tissue diseases Gene Germ-Line Mutation Transcription Factors |
| Zdroj: | Nature Medicine. 7:552-556 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/87876 |
| Popis: | Breast cancer results from genetic and environmental factors leading to the accumulation of mutations in essential genes. Genetic predisposition may have a strong, almost singular effect, as with BRCA1 and BRCA2, or may represent the cumulative effects of multiple low-penetrance susceptibility alleles. Here we review high- and low-penetrance breast-cancer-susceptibility alleles and discuss ongoing efforts to identify additional susceptibility genes. Ultimately these discoveries will lead to individualized breast cancer risk assessment and a reduction in breast cancer incidence. |
| Databáze: | OpenAIRE |
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