Challenges and Opportunities in the Development of HIV Medications in Pediatric Patients
| Autor: | Natella Rakhmanina, B. Ryan Phelps, Gueorgui Dubrocq |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pediatric hiv Anti-HIV Agents Human immunodeficiency virus (HIV) HIV Infections Disease Pharmacology medicine.disease_cause Pediatrics 03 medical and health sciences 0302 clinical medicine Pharmacotherapy medicine Humans Pharmacology (medical) 030212 general & internal medicine Child Intensive care medicine Elvitegravir business.industry Raltegravir 030112 virology Incentive Pill Pediatrics Perinatology and Child Health business medicine.drug |
| Zdroj: | Pediatric Drugs. 19:91-98 |
| ISSN: | 1179-2019 1174-5878 |
| Popis: | Successful management of pediatric HIV disease requires high therapeutic efficacy and adherence, which can be achieved by providing affordable, easy to store, and palatable antiretrovirals. Current challenges in pediatric antiretroviral drug development include poor palatability, large pill size, limited oral liquid formulations, and few incentives for development by drug manufacturers as the number of children with HIV continues to decline due to successful worldwide preventive interventions and improved access to antiretrovirals. This article summarizes the various challenges and opportunities with current pediatric antiretrovirals, recent and ongoing trials, new formulations, and suggestions that may expedite and provide incentives for the development of suitable pediatric formulations. |
| Databáze: | OpenAIRE |
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