| Autor: |
Mu-Sheng Zeng, Xing Zhang, Jennifer R. Grandis, Yun-Fei Xia, Fei Han, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Vivian W.Y. Lui, Jia-Jie Hao, Xin-Yuan Guan, Zi-Feng Wang, Li-Juan Hu, Li-Hua Xu, Ai-Jun Zhou, Yan-min Liu, Li Yuan, Ze-Dong Hu, Zhi-Rui Lin, Zhi-Hua Liu, Qian Zhong |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22465245.v1 |
| Popis: |
S1. Identification of RARS-MAD1L1 by RNA-Seq. S2. RARS-MAD1L1 promotes the proliferation and colony-formation ability of p53-/- MEFs and S26 cells. S3. RARS-MAD1L1 enhances CSC properties in NPC cells. S4. Knockdown of endogenous RARS-MAD1L1 reduces the CSC characteristics of C666-1 cells. S5. Knockdown of RARS-MAD1L1 reduces the oncogenic function of S26 cells induced by RARS-MAD1L1. S6. RARS-MAD1L1 overexpression presents a stronger oncogenic function than wild-type RARS in NPC cells. S7. Knockdown of c-Myc reduces the expression of ABCG2 S8. Schematic illustration of the mechanism through which RARS-MAD1L1 induces cancer stem cell properties and therapeutic resistance through the FBP1/c-Myc axis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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