Sensitisation to common allergens and respiratory symptoms in endotoxin exposed workers: a pooled analysis
| Autor: | Basinas, I., Schlünssen, V., Heederik, D., Sigsgaard, T., Smit, L.A., Samadi, S., Omland, O., Hjort, C., Madsen, A.M., Skov, S., Wouters, I.M., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS |
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| Přispěvatelé: | Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Chronic bronchitis Denmark Logistic regression Immunoglobulin E 0302 clinical medicine Risk Factors Epidemiology Odds Ratio Prevalence Medicine Young adult Child Netherlands 2. Zero hunger biology Agriculture Dust Middle Aged 030210 environmental & occupational health 3. Good health Occupational Diseases Hay fever Female Adult medicine.medical_specialty Adolescent Coronacrisis-Taverne Air Pollutants Occupational Young Adult 03 medical and health sciences Occupational Exposure Hypersensitivity Humans Occupations Risk factor Bronchitis business.industry Public Health Environmental and Occupational Health Rhinitis Allergic Seasonal Odds ratio Allergens medicine.disease Endotoxins Logistic Models 030228 respiratory system Immunology biology.protein business |
| Zdroj: | Occupational and Environmental Medicine, 69(2), 99. BMJ Publishing Group Ltd Basinas, I, Schlünssen, V, Heederik, D, Sigsgaard, T, Smit, L A M, Samadi, S, Omland, Ø, Hjort, C, Madsen, A M, Skov, S & Wouters, I M 2012, ' Sensitisation to common allergens and respiratory symptoms in endotoxin exposed workers: a pooled analysis ', Occupational and Environmental Medicine, vol. 69, no. 2, pp. 99-106 . https://doi.org/10.1136/oem.2011.065169 |
| ISSN: | 1351-0711 |
| DOI: | 10.1136/oem.2011.065169 |
| Popis: | Objective To test the hypotheses that current endotoxin exposure is inversely associated with allergic sensitisation and positively associated with non-allergic respiratory diseases in four occupationally exposed populations using a standardised analytical approach. Methods Data were pooled from four epidemiological studies including 3883 Dutch and Danish employees in veterinary medicine, agriculture and power plants using biofuel. Endotoxin exposure was estimated by quantitative job-exposure matrices specific for the study populations. Dose–response relationships between exposure, IgE-mediated sensitisation to common allergens and self-reported health symptoms were assessed using logistic regression and generalised additive modelling. Adjustments were made for study, age, sex, atopic predisposition, smoking habit and farm childhood. Heterogeneity was assessed by analysis stratified by study. Results Current endotoxin exposure was dose-dependently associated with a reduced prevalence of allergic sensitisation (ORs of 0.92, 0.81 and 0.66 for low mediate, high mediate and high exposure) and hay fever (ORs of 1.16, 0.81 and 0.58). Endotoxin exposure was a risk factor for organic dust toxic syndrome, and levels above 100 EU/m3 significantly increased the risk of chronic bronchitis (p |
| Databáze: | OpenAIRE |
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