New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis
| Autor: | Jana Adamcakova, Daniela Mokra |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
Inflammasomes Silicosis Anti-Inflammatory Agents Inflammation Review Therapeutic targeting Catalysis Antioxidants Inorganic Chemistry Fibrosis medicine oxidative stress Animals Humans Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Lung business.industry Pneumoconiosis Macrophages lung fibrosis Organic Chemistry Lung fibrosis General Medicine respiratory system medicine.disease Computer Science Applications Chemistry medicine.anatomical_structure silica inflammation Nodular lesions Immunology Cytokines medicine.symptom business |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 4162, p 4162 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Inhalation of silica particles is an environmental and occupational cause of silicosis, a type of pneumoconiosis. Development of the lung silicosis is a unique process in which the vicious cycle of ingestion of inhaled silica particles by alveolar macrophages and their release triggers inflammation, generation of nodular lesions, and irreversible fibrosis. The pathophysiology of silicosis is complex, and interactions between the pathomechanisms have not been completely understood. However, elucidation of silica-induced inflammation cascades and inflammation-fibrosis relations has uncovered several novel possibilities of therapeutic targeting. This article reviews new information on the pathophysiology of silicosis and points out several promising treatment approaches targeting silicosis-related pathways. |
| Databáze: | OpenAIRE |
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