Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits

Autor: E. Zambrano, Francisco Castelán, Y. Carrillo-Portillo, Maribel Méndez-Tepepa, Julia Rodríguez-Castelán, Jorge Rodríguez-Antolín, Arely Anaya-Hernández, Estela Cuevas-Romero
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
medicine.medical_specialty
endocrine system
Article Subject
endocrine system diseases
Adipose tissue
lcsh:Medicine
Inflammation
General Biochemistry
Genetics and Molecular Biology
Muscle hypertrophy
03 medical and health sciences
chemistry.chemical_compound
Aromatase
0302 clinical medicine
Hypothyroidism
Ovarian Follicle
Internal medicine
Adipocytes
medicine
Animals
030219 obstetrics & reproductive medicine
General Immunology and Microbiology
biology
CD68
Macrophages
Leptin
lcsh:R
nutritional and metabolic diseases
Hypertrophy
Organ Size
General Medicine
medicine.disease
030104 developmental biology
Endocrinology
Adipose Tissue
chemistry
biology.protein
Uric acid
Female
Rabbits
medicine.symptom
Infiltration (medical)
hormones
hormone substitutes
and hormone antagonists
Research Article
Zdroj: BioMed Research International, Vol 2017 (2017)
BioMed Research International
ISSN: 2314-6141
2314-6133
Popis: Ovarian failure is related to dyslipidemias and inflammation, as well as to hypertrophy and dysfunction of the visceral adipose tissue (VAT). Although hypothyroidism has been associated with obesity, dyslipidemias, and inflammation in humans and animals, its influence on the characteristics of ovarian follicles in adulthood is scarcely known. Control and hypothyroid rabbits were used to analyze the ovarian follicles, expression of aromatase in the ovary, serum concentration of lipids, leptin, and uric acid, size of adipocytes, and infiltration of macrophages in the periovarian VAT. Hypothyroidism did not affect the percentage of functional or atretic follicles. However, it reduced the size of primary, secondary, and tertiary follicles considered as large and the expression of aromatase in the ovary. This effect was associated with high serum concentrations of total cholesterol and low-density lipoprotein cholesterol (LDL-C). In addition, hypothyroidism induced hypertrophy of adipocytes and a major infiltration of CD68+ macrophages into the periovarian VAT. Our results suggest that the reduced size of ovarian follicles promoted by hypothyroidism could be associated with dyslipidemias, hypertrophy, and inflammation of the periovarian VAT. Present findings may be useful to understand the influence of hypothyroidism in the ovary function in adulthood.
Databáze: OpenAIRE
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