Chalcone Derivatives Suppress Proliferation and Migration of Castration-resistant Prostate Cancer Cells Through FAK-mediated DNA Damage

Autor:	Hainiao, Xiao, Zhigang, Wu, Qinquan, Wang, Chaofeng, Zhou, Feng, Lu, Yunbei, Xiao
Rok vydání:	2022
Předmět:	Male Molecular Docking Simulation Prostatic Neoplasms Castration-Resistant Cancer Research Chalcones Chalcone Oncology Focal Adhesion Protein-Tyrosine Kinases Cell Line Tumor Humans Apoptosis General Medicine Cell Proliferation
Zdroj:	Anticancer Research. 43:389-403
ISSN:	1791-7530 0250-7005
DOI:	10.21873/anticanres.16174
Popis:	Castration-resistant prostate cancer (CRPC) contributes to the deaths of most men from prostate cancer. Focal adhesion kinase (FAK) is abnormally up-regulated in CRPC. Chalcone possesses potent anticancer activity with clinical potential. However, it remains unknown whether its derivatives can be exploited as promising oncotherapeutic agents in CRPC treatment by inhibiting FAK-related signaling pathway.This study aimed to investigate the anticancer effects and the underlying mechanisms of action of chalcone derivatives against CRPC cells.Two chalcone derivatives (compoundsThe results revealed that both compounds exhibited stronger cytotoxicity to CRPC cells along with significant inhibition of colony formation, especially compoundWe discovered two chalcone derivatives and collective results indicated that
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec89f68290931c321a7715f8ebdc276 https://doi.org/10.21873/anticanres.16174 Zobrazit plný text záznamu