Creatine Supplementation Reduces Doxorubicin-Induced Cardiomyocellular Injury
| Autor: | Marcus D. Darrabie, Bryan J. Feger, Rajashree Mishra, Danny O. Jacobs, Lucia Santacruz, Jose G. Mantilla |
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| Rok vydání: | 2014 |
| Předmět: |
Cell Survival
Creatine transport Pharmacology Toxicology Creatine Rats Sprague-Dawley chemistry.chemical_compound polycyclic compounds medicine Animals Myocytes Cardiac Doxorubicin Cytotoxicity Molecular Biology Cells Cultured chemistry.chemical_classification Cardiotoxicity Reactive oxygen species Antibiotics Antineoplastic business.industry medicine.disease Rats carbohydrates (lipids) Animals Newborn Biochemistry chemistry Apoptosis Heart failure Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovascular Toxicology. 15:180-188 |
| ISSN: | 1559-0259 1530-7905 |
| Popis: | Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creatine transport, which is the cell's sole source of creatine. We present the results of a study performed to determine if physiological creatine supplementation (5 mmol/L) could protect cardiomyocytes in culture from cellular injury resulting from exposure to therapeutic levels of DOX. Creatine supplementation significantly decreased cytotoxicity, apoptosis, and reactive oxygen species production caused by DOX. The protective effect was specific to creatine and depended on its transport into the cell. |
| Databáze: | OpenAIRE |
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