Anti-diabetic and lipid-lowering effects of drimane sesquiterpenoids isolated from Zygogynum pancheri

Autor: Henda Keskes, Olfa Hentati, Marc Litaudon, Sahla Belhadj, Fanny Roussi, Noureddine Allouche, Cécile Apel
Přispěvatelé: Université de Sfax - University of Sfax, Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
ALT
[SDV]Life Sciences [q-bio]
FBG
dimethyl sulfoxide
Toxicology
Abbreviations: T2D
Fasting Blood Glucose
chemistry.chemical_compound
0302 clinical medicine
aspartate aminotransferase
STZ
Winteraceae
Alanine aminotransferase
DMSO
triglycerides
Hypolipidemic Agents
T-Ch
Traditional medicine
total cholesterol
streptozotocine
General Medicine
3. Good health
030220 oncology & carcinogenesis
Alkaline phosphatase
HDL-c
type 2 diabetes
Lipid lowering
Sesquiterpenes
alkaline phosphatase
medicine.drug
LDH
alanine aminotransferase
Diabetes Mellitus
Experimental
03 medical and health sciences
Zygogynum pancheri
New Caledonia
TGs
high-density lipoprotein cholesterol
Total cholesterol
Lactate dehydrogenase
medicine
Animals
Hypoglycemic Agents
[CHIM]Chemical Sciences
Rats
Wistar
AST
Polycyclic Sesquiterpenes
Plant Extracts
Dimethyl sulfoxide
lactate dehydrogenase
Streptozotocin
Rats
030104 developmental biology
chemistry
ALP
Anti-Obesity Agents
Phytotherapy
Zdroj: Chemico-Biological Interactions
Chemico-Biological Interactions, Elsevier, 2020, ⟨10.1016/j.cbi.2020.109167⟩
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2020.109167
Popis: International audience; Background: Recently, it has been shown that drimane-type sesquiterpenoids isolated from Zygogynum pancheri, a species native to New Caledonia, possessed significant α-amylase inhibitory activities. Purpose: To further explore their antidiabetic potential, we investigated the effect of 1β-O-(E-cinnamoyl)-6α-hydroxy-9epi-polygodial (D) and 1β-E-O-p-methoxycinnamoyl-bemadienolide (L), two of the most active compounds of the series, on diabetic model rats. Methods: Compounds D and L (2 mg kg/day) were daily and orally administrated for 30 days to streptozotocin (STZ) (150 mg/kg) induced male diabetic Wistar rats. Animals were allocated into five groups of six rats.Results: Comparatively to diabetic rats, treatments with D and L compounds were able to significantly (P < 0.05) decrease Fasting Blood Glucose (FBG) (70.15%, 71.02%), serum total cholesterol (46.27% and 39.38%), triglycerides (56.60% and 58.15%), creatinine (37.31% and 36.49%) and uric acid levels (67.76% and 69.68%), respectively. Compounds D and L also restored the altered plasma enzyme (aspartate aminotransferase, AST (47.83% and 43.20%), alanine aminotransferase, ALT (49.76% and 48.35%, alkaline phosphatase, ALP (72.78% and 73.21%)) and lactate dehydrogenase, LDH (47.95% and 53.93%) levels to near normal, respectively. Administration of Glymepiride, significantly (p
Databáze: OpenAIRE
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