Antioxidants as Antiarrhythmic Drugs
| Autor: | Yu.V. Khmelevsky, S.F. Golovchenko, V.G. Shevchuk, L.S. Mkhitarjan, V.V. Frolkis, N.B. Poberezkina, V.A. Tsyomik, Frol'kis Ra, Voronkov Gs, I.V. Lysenko, G. Ya. Dubur |
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| Rok vydání: | 1987 |
| Předmět: |
Male
inorganic chemicals medicine.medical_specialty Vasopressin Antioxidant Epinephrine Pyridines Vasopressins medicine.medical_treatment macromolecular substances Antioxidants Internal medicine Strophanthins medicine Animals Vitamin E Pharmacology (medical) Chemotherapy Lagomorpha biology business.industry Arrhythmias Cardiac Butylated Hydroxytoluene biology.organism_classification Rats Endocrinology Strophanthin Rabbits Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiology. 74:124-132 |
| ISSN: | 1421-9751 0008-6312 |
| DOI: | 10.1159/000174186 |
| Popis: | Experiments on rats and rabbits using models of arrhythmias induced by vasopressin, epinephrine, strophanthin, and CaCl2 showed that antioxidants derived from 1,4-dihydropyridines, dibunol, and alpha-tocopherol possessed antiarrhythmic effects. Administration of these antioxidants decreased the occurrence of extrasystoles, disturbances of atrioventricular conductivity and ventricular fibrillation. These drugs also prevented changes in membrane phospholipid composition, inhibited activation of peroxidation, decreased phospholipase activity, prevented a decrease of Ca2+ ATPase and Ca2+ binding and uptake by sarcoplasmic reticulum, and increased sarcolemmal Na+, K+-ATPase, sarcoplasmic reticulum creatine phosphokinase. |
| Databáze: | OpenAIRE |
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