Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial
| Autor: | Elias Dakwar, Rebecca L Rothberg, Nour Azhari, Nancy A. Haug |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Hallucinogen
Male medicine.medical_specialty Alcohol Drinking Substance-Related Disorders Midazolam Alcohol use disorder Dissociative Disorders law.invention 03 medical and health sciences At risk drinking 0302 clinical medicine Randomized controlled trial Double-Blind Method law Surveys and Questionnaires Spirituality Medicine Humans Pharmacology (medical) Ketamine Psychiatry Pharmacology business.industry Motivational enhancement therapy Middle Aged medicine.disease 030227 psychiatry Behavior Addictive Psychiatry and Mental health Treatment Outcome Hallucinogens Female Substance use business 030217 neurology & neurosurgery medicine.drug Mysticism |
| Zdroj: | Journal of psychopharmacology (Oxford, England). 35(2) |
| ISSN: | 1461-7285 |
| Popis: | Background: Sub-anesthetic ketamine administration may be helpful for substance use disorders. Converging evidence suggests that the efficacy of ketamine for certain conditions may implicate a subset of its psychoactive effects. Aims: The aim of this analysis is to evaluate whether the mystical-type effects of ketamine are critical for clinical efficacy in alcohol-dependent individuals. In this secondary analysis, we determine if a subset of the psychoactive effects of ketamine, the so-called mystical-type experience, mediates the effect of ketamine, when combined with motivational enhancement therapy, on at-risk drinking behavior in alcohol-dependent individuals interested in treatment. Methods: Forty alcohol dependent adults were randomized to either a 52-minute infusion of ketamine or midazolam, which they received on a designated quit-day during the second week of a five-week motivational enhancement therapy regimen. Psychoactive effects were assessed following the infusion, and alcohol use was monitored for the subsequent 3 weeks at each twice-weekly visit. Results: We found that ketamine leads to significantly greater mystical-type effects (by Hood Mysticism Scale) and dissociation (by Clinician Administered Dissociative States Scale) compared to the active control. Ketamine also led to significant reduction in at-risk drinking. The Hood Mysticism Scale, but not Clinician Administered Dissociative States Scale score, was found to mediate the effect of ketamine on drinking behavior. Conclusions: This trial adds evidence to the literature on the importance of mystical-type experiences in addiction treatment. Future research should continue to investigate the relationship between the psychoactive effects of psychedelic therapeutics and clinical outcomes for other substance use and mental health disorders. |
| Databáze: | OpenAIRE |
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