Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection
| Autor: | Tracie L. Miller, Enxu Zhao, Deshratn Asthana, Heidi Schwarzwald, F. Daniel Armstrong, Chivon McMullen-Jackson, William T. Shearer, Steven E. Lipshultz, Lynnette L. Harris, Ming Lu, Shahriar Shahzeidi, Andrew A. Colin, Samuel B. Foster, Daniel G. Glaze, Charla Clark, Bang Ning Lee, Bruce W. Thompson, Gwendolyn B. Scott, Elizabeth J. Willen, James M. Reuben, Pim Brouwers, Evan N. Cohen, Mary E. Paul |
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| Rok vydání: | 2012 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Adolescent media_common.quotation_subject medicine.medical_treatment Immunology Psychological intervention HIV Infections Child Behavior Disorders CD8-Positive T-Lymphocytes Neuropsychological Tests Article Cohort Studies Executive Function Memory Humans Immunology and Allergy Medicine Child media_common business.industry Executive functions Cytokine Cytokines Female Verbal memory Cognition Disorders Sleep business Neurocognitive Psychosocial Vigilance (psychology) Cohort study |
| Zdroj: | Clinical Immunology. 144:13-23 |
| ISSN: | 1521-6616 |
| DOI: | 10.1016/j.clim.2012.04.004 |
| Popis: | Youth infected with HIV at birth often have sleep disturbances, neurocognitive deficits, and abnormal psychosocial function which are associated with and possibly resulted from elevated blood cytokine levels that may lead to a decreased quality of life. To identify molecular pathways that might be associated with these disorders, we evaluated 38 HIV-infected and 35 uninfected subjects over 18-months for intracellular cytokine levels, sleep patterns and duration of sleep, and neurodevelopmental abilities. HIV infection was significantly associated with alterations of intracellular pro-inflammatory cytokines (TNF-α, IFN-γ, IL-12), sleep factors (total time asleep and daytime sleep patterns), and neurocognitive factors (parent and patient reported problems with socio-emotional, behavioral, and executive functions; working memory-mental fatigue; verbal memory; and sustained concentration and vigilance. By better defining the relationships between HIV infection, sleep disturbances, and poor psychosocial behavior and neurocognition, it may be possible to provide targeted pharmacologic and procedural interventions to improve these debilitating conditions. |
| Databáze: | OpenAIRE |
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