Anti-inflammatory coating of hernia repair meshes: a 5-rabbit study
| Autor: | Dmitry Gil, Vladimir Reukov, Mikhail Bredikhin, Alexey Vertegel, William S. Cobb, James Rex |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Pathology Hernia Biocompatibility medicine.medical_treatment Anti-Inflammatory Agents Inflammation Pilot Projects Polypropylene mesh 030230 surgery medicine.disease_cause Polypropylenes 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo medicine Vitamin E Animals Herniorrhaphy Rabbit model business.industry Abdominal Wall Surgical Mesh medicine.disease Hernia repair Surgery Disease Models Animal chemistry 030220 oncology & carcinogenesis Original Article Rabbits medicine.symptom business Oxidative stress |
| Zdroj: | Hernia |
| ISSN: | 1248-9204 1265-4906 |
| Popis: | Purpose Polymeric mesh implantation has become the golden standard in hernia repair, which nowadays is one of the most frequently performed surgeries in the world. However, many biocompatibility issues remain to be a concern for hernioplasty, with chronic pain being the most notable post-operative complication. Oxidative stress appears to be a major factor in the development of those complications. Lack of material inertness in vivo and oxidative environment formed by inflammatory cells result in both mesh deterioration and slowed healing process. In a pilot in vivo study, we prepared and characterized polypropylene hernia meshes with vitamin E (α-tocopherol)-a potent antioxidant. The results of that study supported the use of vitamin E as potential coating to alleviate post-surgical inflammation, but the pilot nature of the study yielded limited statistical data. The purpose of this study was to verify the observed trend of the pilot study statistically. Methods In this work, we conducted a 5-animal experiment where we have implanted vitamin E-coated and uncoated control meshes into the abdominal walls of rabbits. Histology of the mesh-adjacent tissues and electron microscopy of the explanted mesh surface were conducted to characterize host tissue response to the implanted meshes. Results As expected, modified meshes exhibited reduced foreign body reaction, as evidenced by histological scores for fatty infiltrates, macrophages, neovascularization, and collagen organization, as well as by the surface deterioration of the meshes. Conclusion In conclusion, results indicate that vitamin E coating reduces inflammatory response following hernioplasty and protects mesh material from oxidative deterioration. |
| Databáze: | OpenAIRE |
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