The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn
| Autor: | Bryan J. Song, Anda M. Chirila, Thomas G. O'Neill, Amanda Zimmerman, Sacha B. Nelson, Ling Bai, David D. Ginty, Lauren L. Orefice, Connie Tsan, Mark W. Springel, Justin Zhuo, Jessica Hoynoski, David Hughes, Nathaniel Heintz, Laura Kus, Masahiko Watanabe, Karleena A. Bashista, Vera Niederkofler, Victoria E. Abraira, Emily D. Kuehn, Susan M. Dymecki, Michael Rutlin, Alexis A. Toliver, Kieran A. Boyle |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
genetic structures Interneuron Biology Somatosensory system Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Mice Interneurons Spinal Cord Dorsal Horn Neural Pathways medicine Animals Molecular Biology Biochemistry Genetics and Molecular Biology(all) Dendrites Tactile perception Spinal cord Axons Mechanoreceptor 030104 developmental biology medicine.anatomical_structure nervous system Spinal Cord Touch Perception Synapses Excitatory postsynaptic potential Neuroscience Mechanoreceptors |
| Zdroj: | Cell. 168(1-2) |
| ISSN: | 1097-4172 0092-8674 |
| Popis: | The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LTMR-RZ processing in tactile perception, and the basic logic of LTMR-RZ organization. We found an unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiological, and synaptic properties. Remarkably, LTMRs form synapses on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons. Thus, the LTMR-RZ is a somatosensory processing region endowed with a neuronal complexity that rivals the retina and functions to pattern the activity of ascending touch pathways that underlie tactile perception. |
| Databáze: | OpenAIRE |
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