Posttransplant Urinary Tract Infection Rates and Graft Outcome in Kidney Transplantation for End-Stage Renal Disease Due to Reflux Nephropathy Versus Chronic Glomerulonephritis
| Autor: | A. Unsal, T. Sakaci, Cuneyt Akgol, Elbis Ahbap, M. Sevinc, T. Basturk, Zuhal Atan Ucar, Arzu Ozdemir Kayalar, Tuncay Sahutoglu, Y. Koc, Nurhan Seyahi, Ekrem Kara |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Urinary system Urology 030230 surgery urologic and male genital diseases Vesicoureteral reflux Nephrectomy End stage renal disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glomerulonephritis Postoperative Complications medicine Humans Renal replacement therapy Kidney transplantation Retrospective Studies Reflux nephropathy Vesico-Ureteral Reflux Transplantation Creatinine Pyelonephritis business.industry Graft Survival medicine.disease Kidney Transplantation female genital diseases and pregnancy complications Tissue Donors Surgery chemistry Chronic Disease Urinary Tract Infections Kidney Failure Chronic 030211 gastroenterology & hepatology Female Kidney Diseases business |
| Zdroj: | Transplantation proceedings. 48(6) |
| ISSN: | 1873-2623 |
| Popis: | Background The goal of this study was to evaluate posttransplant urinary tract infection (UTI) rates and graft outcome in kidney transplantation for end-stage renal disease (ESRD) due to vesicoureteral reflux (VUR)-related reflux nephropathy (RN) versus chronic glomerulonephritis (CGN). Methods A total of 62 patients with ESRD who underwent kidney transplantation for VUR-related RN (VUR-RN group, n = 31; mean ± standard deviation age, 34.1 ± 6.0 years; 58.1% female) or CGN (CGN group, n = 31; mean age, 34.2 ± 6.8 years; 71.0% male) at our unit between January 1996 and January 2011 were included in this retrospective study. Baseline recipient and donor characteristics, renal replacement therapy, posttransplant data on serum creatinine levels, graft outcome, and UTIs were recorded. Posttransplant UTIs and graft outcome were compared between the VUR-RN and CGN groups, as well as between patients with and without pretransplant nephrectomy in the VUR-RN group. Results The frequency of overall (72 vs 18 of 90; P = .05) UTI episodes was significantly higher in the VUR-RN group than in the CGN group; Escherichia coli (64.2%) was the most common pathogen. The VUR-RN and CGN groups were similar in terms of 1-year (100.0% for each), 5-year (95.8% vs 96.8%), and 10-year (82.0% vs 96.8%) graft survival. VUR-RN patients with and without nephrectomy were similar in terms of 1-year (100.0% for each), 5-year (91.7% vs 85.7%), and 10-year (81.5% vs 85.7%) graft survival. Conclusions Our findings indicate kidney transplantation is a safe and effective option in ESRD patients with RN secondary to VUR. It resulted in high 1-year, 5-year, and 10-year graft survival rates. |
| Databáze: | OpenAIRE |
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