Nitric oxide influences blood flow distribution in renovascular hypertension
| Autor: | W H Beierwaltes, D H Sigmon |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure Arginine Kidney Nitric Oxide Renal artery stenosis Renal Circulation Renovascular hypertension Nitric oxide Rats Sprague-Dawley chemistry.chemical_compound Reference Values Coronary Circulation Internal medicine Internal Medicine medicine Animals Renal circulation business.industry Cerium Radioisotopes Hemodynamics Brain medicine.disease Microspheres Hindlimb Rats Hypertension Renovascular NG-Nitroarginine Methyl Ester medicine.anatomical_structure Blood pressure Endocrinology chemistry Regional Blood Flow Strontium Cerebrovascular Circulation Renal blood flow Vascular resistance Vascular Resistance business |
| Zdroj: | Hypertension. 23 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Endothelium-derived nitric oxide contributes to the regulation of regional blood flow. Inhibition of endothelium-derived nitric oxide synthesis increases blood pressure and vascular resistance. Using the substrate antagonist N omega-nitro-L-arginine-methyl ester to block endothelium-derived nitric oxide synthesis, we tested the hypothesis that, in two-kidney, one clip renovascular hypertension, endothelium-derived nitric oxide plays an increased role in maintaining blood flow to the nonclipped kidney and other visceral organs compared with normotensive controls. This could be due to increased vascular shear stress, a primary stimulus for endothelium-derived nitric oxide synthesis, after the onset of hypertension. In hypertensive rats with mild renal artery stenosis, basal renal blood flow normalized by kidney weight was similar in the nonclipped and clipped kidneys. Basal blood pressure of controls was 98 +/- 2 mm Hg compared with 145 +/- 3 mm Hg in the two-kidney, one clip hypertensive rats. N omega-nitro-L-arginine-methyl ester increased blood pressure by 20 +/- 2 and 43 +/- 3 mm Hg in control and hypertensive rats, respectively. Compared with normotensive controls, basal resistance was higher in all organ beds in the hypertensive rats including brain, heart, intestine, and kidney. With the exception of the renal circulation, the increase in vascular resistance after N omega-nitro-L-arginine-methyl ester was greater in hypertensive rats compared with normotensive controls. In the hypertensive rats, N omega-nitro-L-arginine-methyl ester caused a similar increase in vascular resistance in both the nonclipped and clipped kidneys, and this was not different from normotensive controls.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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