Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic

Autor:	Sajad Khiali, Elnaz Khani, Samineh Beheshtirouy, Taher Entezari-Maleki
Rok vydání:	2022
Předmět:	Microbiology (medical) SARS-CoV-2 Humans Cytidine Hydroxylamines Antiviral Agents Pandemics Microbiology COVID-19 Drug Treatment
Zdroj:	Future Microbiology. 17:377-391
ISSN:	1746-0921 1746-0913
Popis:	Despite the progress in the management of COVID-19, effective oral antiviral agents are still lacking. In the present review, the potential beneficial effects of molnupiravir in the management of COVID-19 are discussed. A literature search in Google Scholar, Scopus, PubMed and clinicaltrials.gov for the relevant articles regarding the pharmacokinetics, pharmacodynamics and clinical trials of molnupiravir in the management of COVID-19 is conducted. Most of the preclinical studies and available clinical trials showed a favorable short-term safety profile of molnupiravir; however, given its possible genotoxic effects, further trials are required to confirm the long-term efficacy and safety of molnupiravir in patients with COVID-19.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6a9435aa68c1da2e07a10bb49094f3 https://doi.org/10.2217/fmb-2021-0252 Zobrazit plný text záznamu