Clinical significance of plasma free DNA in patients with non-small cell lung cancer
| Autor: | Jie Du, Lanxiang Ma, Shuili Wang, Yongjie Sui |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Medicine (General) Lung Neoplasms Clinical Research Reports Biochemistry Free dna 03 medical and health sciences 0302 clinical medicine plasma free DNA R5-920 Non-small cell lung cancer Carcinoma Non-Small-Cell Lung medicine Humans Clinical significance In patient Lung cancer Aged therapy business.industry Biochemistry (medical) Cell Biology General Medicine DNA Middle Aged Reference Standards medicine.disease respiratory tract diseases 030104 developmental biology clinical diagnosis 030220 oncology & carcinogenesis Clinical diagnosis Case-Control Studies polymerase chain reaction (PCR) Cancer research Biomarker (medicine) biomarker Female Non small cell business |
| Zdroj: | Journal of International Medical Research, Vol 47 (2019) The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Objectives Plasma free DNA is a promising new tumor biomarker, which may have applications in clinical diagnosis and treatment of non-small cell lung cancer (NSCLC). Methods Plasma free DNA was collected from 120 healthy controls and 116 patients with NSCLC before and after treatment. Results The mean plasma free DNA levels in 116 NSCLC patients (200.70 ± 88.54 ng/mL) were higher than those of 120 healthy controls (18.65 ± 6.30 ng/mL). Further analysis showed that the mean serum free DNA level in stage I/II NSCLC patients was 172.75 ± 72.87 ng/mL, significantly lower than that of stage III/IV patients (221.88 ± 93.86 ng/mL). Following surgery and effective chemotherapy, the plasma free DNA levels of NSCLC patients decreased significantly. Conclusions Through quantitation of plasma free DNA, this study established proof-of-concept for a highly sensitive and specific detection method, which can be used for diagnosis, prognosis and treatment monitoring in NSCLC patients. |
| Databáze: | OpenAIRE |
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