Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development
| Autor: | Frédérique Barloy-Hubler, Leslie Ratié, Isabelle Gicquel, Christèle Dubourg, Hélène Romé, Véronique David, Valérie Dupé, Michelle Ware |
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| Přispěvatelé: | Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), AMADEUS (AMADEUS), Amadeus, This work was supported by the Agence Nationale de la Recherche (grant no. ANR-12-BSV1-0007-01, VD)., ANR-12-BSV1-0007,HOLOPRO,Etude des mécanismes moléculaires impliqués dans l'holoprosencéphalie(2012), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Notch
Regulator Notch signaling pathway Hypothalamus Gene Expression Proneural genes Chick Embryo 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Lateral inhibition Animals Enzyme Inhibitors 030304 developmental biology 0303 health sciences biology Receptors Notch Effector Neurogenesis Up-Regulation Notch proteins nervous system Neuronal differentiation biology.protein [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Amyloid Precursor Protein Secretases Amyloid precursor protein secretase Neuroscience 030217 neurology & neurosurgery Research Article Signal Transduction Embryonic brain |
| Zdroj: | Neural Development Neural Development, 2013, 8, pp.25. ⟨10.1186/1749-8104-8-25⟩ Neural Development, BioMed Central, 2013, 8, pp.25. ⟨10.1186/1749-8104-8-25⟩ |
| ISSN: | 1749-8104 |
| DOI: | 10.1186/1749-8104-8-25⟩ |
| Popis: | International audience; BACKGROUND: The generation of diverse neuronal types and subtypes from multipotent progenitors during development is crucial for assembling functional neural circuits in the adult central nervous system. It is well known that the Notch signalling pathway through the inhibition of proneural genes is a key regulator of neurogenesis in the vertebrate central nervous system. However, the role of Notch during hypothalamus formation along with its downstream effectors remains poorly defined. RESULTS: Here, we have transiently blocked Notch activity in chick embryos and used global gene expression analysis to provide evidence that Notch signalling modulates the generation of neurons in the early developing hypothalamus by lateral inhibition. Most importantly, we have taken advantage of this model to identify novel targets of Notch signalling, such as Tagln3 and Chga, which were expressed in hypothalamic neuronal nuclei. CONCLUSIONS: These data give essential advances into the early generation of neurons in the hypothalamus. We demonstrate that inhibition of Notch signalling during early development of the hypothalamus enhances expression of several new markers. These genes must be considered as important new targets of the Notch/proneural network. |
| Databáze: | OpenAIRE |
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