The Architecture and Conservation Pattern of Whole-Cell Control Circuitry
| Autor: | Lucy Shapiro, Harley H. McAdams |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Caulobacter
Distributed computing Cell Cycle Control (management) Cell Cycle Proteins Gene Expression Regulation Bacterial Cell cycle Biology Article Cell biology Bacterial Proteins Structural Biology Asynchronous communication Control system Asymmetric cell division Systems design Cell Cycle Protein Molecular Biology Conserved Sequence |
| Zdroj: | Journal of Molecular Biology. 409:28-35 |
| ISSN: | 0022-2836 |
| DOI: | 10.1016/j.jmb.2011.02.041 |
| Popis: | The control circuitry that directs and paces Caulobacter cell cycle progression involves the entire cell operating as an integrated system. This control circuitry monitors the environment and the internal state of the cell, including the cell topology, as it orchestrates orderly activation of cell cycle subsystems and Caulobacter's asymmetric cell division. The proteins of the Caulobacter cell cycle control system and its internal organization are co-conserved across many alpha-proteobacteria species, but there are great differences in the regulatory apparatus’ functionality and peripheral connectivity to other cellular subsystems from species to species. This pattern is similar to that observed for the “kernels” of the regulatory networks that regulate development of metazoan body plans. The Caulobacter cell cycle control system has been exquisitely optimized as a total system for robust operation in the face of internal stochastic noise and environmental uncertainty. When sufficient details accumulate, as for Caulobacter cell cycle regulation, the system design has been found to be eminently rational and indeed consistent with good design practices for human-designed asynchronous control systems. |
| Databáze: | OpenAIRE |
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