Up-regulation of angiotensin-converting enzyme and angiotensin II type 1 receptor in irradiated rats

Autor:	Paulo Cesar Canary, Januário B. Cabral-Neto, Luiz Dione Barbosa De Melo, Nazareth N. Rocha, Luis Alexandre Gonçalves Magalhães, Andréia Fortes Ribeiro, Andre Luiz Mencalha, Samara Cristina Ferreira-Machado, Camila Salata, Carlos Alberto Mandarim-de-Lacerda, Thiago da Silva Torres, C. E. deAlmeida, Antônio Augusto de Freitas Peregrino
Rok vydání:	2010
Předmět:	Male medicine.medical_specialty Stereology Peptidyl-Dipeptidase A Collagen Type I Receptor Angiotensin Type 1 Renin-Angiotensin System Transforming Growth Factor beta1 Internal medicine Renin–angiotensin system medicine Animals Myocytes Cardiac Radiology Nuclear Medicine and imaging Rats Wistar Receptor Ejection fraction Angiotensin II receptor type 1 Radiological and Ultrasound Technology biology Chemistry Dose-Response Relationship Radiation Heart Angiotensin-converting enzyme Angiotensin II Rats Up-Regulation Blot Endocrinology biology.protein
Zdroj:	International Journal of Radiation Biology. 86:880-887
ISSN:	1362-3095 0955-3002
DOI:	10.3109/09553002.2010.492489
Popis:	To investigate changes in cardiac functional parameters and the cardiac expression of angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1), procollagen type I (proc-I) and transforming growth factor-ß1 (TGF-ß1) in rats irradiated at heart.Male Wistar rats were irradiated with a single dose of radiation (0, 5, 10 and 15 Gray [Gy]) delivered directly to the heart and the molecular evaluations were performed at various times post-irradiation (two days, 15 days and four months). The expression of ACE, AT1, proc-I and TGF-ß1 were analysed using Real Time-Polymerase Chain Reaction (RT-PCR) and/or Western blotting. Cardiac structural and functional alterations were investigated at the four-month time point by echocardiography and by quantitative methods (stereology).Rats irradiated with 15 Gy showed a modest reduction in the ejection fraction. Cardiac proc-I, TGF-ß1, ACE and AT1 were also measurably increased.Irradiated rat hearts show simultaneous elevations in renin-angiotensin system components AT1 and ACE and cardiac remodeling markers proc-I and TGF-ß1.
Databáze:	OpenAIRE
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