Biologic and imaging diagnosis of lymph node metastasis in esophageal carcinoma
| Autor: | Hiroshi Okumura, Heiji Yoshinaka, Takashi Aikou, Masamichi Baba, Shoji Natsugoe, Hironori Sakita, Masataka Matsumoto, Fuminori Sakamoto, Sonshin Takao, Saburo Nakashima |
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| Rok vydání: | 2002 |
| Předmět: |
Endoscopic ultrasound
Adult Male Pathology medicine.medical_specialty Esophageal Neoplasms Sensitivity and Specificity Metastasis Endosonography Biopsy medicine Carcinoma Humans Prospective Studies Esophagus Lymph node Aged medicine.diagnostic_test Esophageal disease business.industry General Medicine Esophageal cancer Middle Aged medicine.disease medicine.anatomical_structure Oncology Lymphatic Metastasis Carcinoma Squamous Cell Surgery Female business |
| Zdroj: | Journal of surgical oncology. 81(1) |
| ISSN: | 0022-4790 |
| Popis: | Background and Objectives Few reports have described the combined use of biologic and imaging techniques in the diagnosis of lymph node metastasis. We prospectively evaluated lymph node metastasis diagnosed by biologic and imaging means in patients with esophageal carcinoma. Methods Preoperative ultrasound and endoscopic ultrasound (EUS) examination were performed in 80 patients. Biopsy specimens were immunohistochemically examined using cyclin D1 (CD1) and desmoglein 1 (DG1) antibodies, and tumors were classified into three grades. Results The sensitivity, specificity, and accuracy values of ultrasound examination were 88.2, 58.6, and 77.5%, respectively. The incidence of nodal involvement was 0% (0/10) in patients with grade 1 tumors, 57.1% (16/28) in those with grade 2 tumors, and 83.3% (35/42) in those with grade 3 tumors. Of the 57 patients with lymph node metastasis determined sonographically, 50 had grade 2 or 3 tumors that were histologically confirmed. The remaining seven patients with grade 1 tumors did not have involved nodes. Of the 23 patients without lymph node metastasis according to ultrasound examination, the incidence of lymph node metastasis in patients with grade 1, 2, and 3 tumors was 0, 16.7, and 50.0%, respectively. Conclusions When used together, imaging and molecular procedures may offer improved identification of lymph node metastasis in patients with squamous cell carcinoma of the esophagus. J. Surg. Oncol. 2002;81:25–32. © 2002 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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