Hydrogel Synthesis and Stabilization via Tetrazine Click-Induced Secondary Interactions
| Autor: | Lisa M. Pérez, Samantha E. Holt, Faraz Jivan, Daniel L. Alge, Amanda Rakoski |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Supramolecular chemistry Biocompatible Materials 02 engineering and technology macromolecular substances 010402 general chemistry 01 natural sciences Article Polyethylene Glycols chemistry.chemical_compound Tetrazine PEG ratio Materials Chemistry Sulfhydryl Compounds Chemistry Organic Chemistry technology industry and agriculture Hydrogels Dynamic mechanical analysis 021001 nanoscience & nanotechnology 0104 chemical sciences Chemical engineering Covalent bond Self-healing hydrogels Click chemistry Click Chemistry 0210 nano-technology Ethylene glycol |
| Zdroj: | Macromol Rapid Commun |
| ISSN: | 1521-3927 |
| Popis: | The discovery of tetrazine click-induced secondary interactions is reported as a promising new tool for polymeric biomaterial synthesis. This phenomenon is first demonstrated as a tool for poly(ethylene glycol) (PEG) hydrogel assembly via purely non-covalent interactions and is shown to yield robust gels with storage moduli one to two orders of magnitude higher than other non-covalent crosslinking methods. In addition, tetrazine click-induced secondary interactions also enhance the properties of covalently crosslinked hydrogels. A head-to-head comparison of PEG hydrogels crosslinked with tetrazine-norbornene and thiol-norbornene click chemistry reveals an approximately sixfold increase in storage modulus and unprecedented resistance to hydrolytic degradation in tetrazine click-crosslinked gels without substantial differences in gel fraction. Molecular dynamic simulations attribute these differences to the presence of secondary interactions between the tetrazine-norbornene cycloaddition products, which are absent in the thiol-norbornene crosslinked gels. |
| Databáze: | OpenAIRE |
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