Subchronic toxicity of trinitrotoluene in Fischer 344 rats
| Autor: | J.J. Barkley, Paul M Lish, D. E. Gordon, E M Furedi, Barry S Levine |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Hemolytic anemia
Male medicine.medical_specialty Anemia Hematocrit Toxicology Methemoglobin Eating Sex Factors Internal medicine Testis medicine Animals Testicular atrophy medicine.diagnostic_test Dose-Response Relationship Drug Chemistry Body Weight Rats Inbred Strains Organ Size medicine.disease Rats Inbred F344 Rats Endocrinology Cholesterol Liver Splenic Red Pulp Toxicity Histopathology Female Spleen Trinitrotoluene |
| Zdroj: | Toxicology. 32(3) |
| ISSN: | 0300-483X |
| Popis: | This study was conducted to evaluate the toxicity of trinitrotoluene (TNT) in Fischer 344 rats when administered in the diet for 13 weeks. Groups of 10 rats per sex received TNT at doses of 1, 5, 25, 125 or 300 mg/kg/day. Thirty rats per sex served as untreated controls. Toxicologic endpoints included clinical signs, body weight, food consumption, hematology, clinical biochemistry, organ weights and gross/histopathology. Toxic effects following 125 mg/kg/day or greater included decreased food intake and body weight gain, elevated serum cholesterol levels, and anemia (reduced hemoglobin, hematocrit and RBC counts). Splenomegaly, hepatomegaly/hepatocytomegaly and testicular atrophy with degeneration of the seminiferous tubular epithelium were also seen at 125 and 300 mg/kg/day. Hemosiderin-laden macrophages, congestion of the splenic red pulp, methemoglobin production indicative of the oxidizing activity of TNT and/or its metabolites, and the lack of bone marrow toxicity suggested hemolysis as the mechanism of anemia. |
| Databáze: | OpenAIRE |
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