Oxidative stress in chronic otitis media with effusion
| Autor: | Pasquale Gianluca Landolfo, Gaetano Motta, Giuseppina Marcuccio, Germano Guerra, Domenico Testa |
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| Přispěvatelé: | Testa, Domenico, Guerra, Germano, Marcuccio, Giuseppina, Gianluca Landolfo, Pasquale, Motta, Gaetano |
| Rok vydání: | 2012 |
| Předmět: |
Male
Lipid Peroxides medicine.medical_specialty Antioxidant Free Radicals medicine.medical_treatment Chronic otitis Radicali liberi medicine.disease_cause Gastroenterology Myringotomy chemistry.chemical_compound Malondialdehyde Myringoplasty Internal medicine otorhinolaryngologic diseases Humans Medicine Child Lipid peroxide free radicals myringotomy Lipoperossidi Miringotomia Otitis Media with Effusion business.industry General Medicine Glutathione medicine.disease Middle Ear Ventilation Conductive hearing loss Oxidative Stress Otorhinolaryngology chemistry Effusion Spectrophotometry Child Preschool Anesthesia Chronic Disease Female business Oxidative stress Follow-Up Studies |
| Zdroj: | Acta Oto-laryngologica. :1-4 |
| ISSN: | 1651-2251 0001-6489 |
| DOI: | 10.3109/00016489.2012.663504 |
| Popis: | The high oxidant levels in chronic otitis media with effusion (OME) observed in our research and the improvement seen in children with chronic OME after antioxidant treatment suggest that oxygen-derived free radicals play an important role in chronic OME.OME is a common pathologic condition characterized by nonpurulent fluid in the middle ear (ME) that leads to moderate conductive hearing loss and flat tympanogram. During OME inflammatory cells generate large amounts of superoxide radicals to improve bactericidal activity. Overproduction of oxygen-derived free radicals induces oxidative damage in humans. Glutathione (GSH) is one of the major components of the antioxidant system that protects cells from oxidative stress. The aim of the study was to evaluate oxidative stress in chronic OME by investigation of ME fluids collected during myringotomy.During myringotomy, fluid was collected from the ME to evaluate lipid peroxide levels in the effusion. Fifty-nine children with ME effusion without any resolution after repeated medical treatments were enrolled in the study.Lipid peroxide levels in all samples were high (mean 11.5 nmole/million cells), similar to the values found in other chronic diseases. GSH might be employed during surgery while applying ventilation tubes and after surgery to prevent oxidative stress. |
| Databáze: | OpenAIRE |
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