Mps1 promotes poleward chromosome movements in meiotic prometaphase
| Autor: | Dean S. Dawson, Régis E. Meyer, Rebecca LaVictoire, Gary J. Gorbsky, Aaron R. Tipton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Prometaphase
Saccharomyces cerevisiae Proteins Biology Protein Serine-Threonine Kinases Microtubules Spindle pole body Bivalent (genetics) Chromosomes 03 medical and health sciences 0302 clinical medicine Prophase Meiosis Microtubule Homologous chromosome Kinetochores Molecular Biology 030304 developmental biology 0303 health sciences Kinetochore Cell Polarity Cell Biology Articles Cell biology Chromosome Pairing Mutation Saccharomycetales 030217 neurology & neurosurgery |
| Zdroj: | Molecular Biology of the Cell |
| ISSN: | 1939-4586 1059-1524 |
| Popis: | In prophase of meiosis I, homologous chromosomes pair and become connected by cross-overs. Chiasmata, the connections formed by cross-overs, enable the chromosome pair, called a bivalent, to attach as a single unit to the spindle. When the meiotic spindle forms in prometaphase, most bivalents are associated with one spindle pole and then go through a series of oscillations on the spindle, attaching to and detaching from microtubules until the partners of the bivalent become bioriented-attached to microtubules from opposite sides of the spindle. The conserved kinase, Mps1, is essential for the bivalents to be pulled by microtubules across the spindle in prometaphase. Here we show that MPS1 is needed for efficient triggering of the migration of microtubule-attached kinetochores toward the poles and promotes microtubule depolymerization. Our data support the model Mps1 acts at the kinetochore to coordinate the successful attachment of a microtubule and the triggering of microtubule depolymerization to then move the chromosome. |
| Databáze: | OpenAIRE |
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