Transplant Center Volume and the Risk of Pancreas Allograft Failure
| Autor: | Jason R. Wellen, Tarek Alhamad, Krista L. Lentine, Andrew F. Malone, Su-Hsin Chang, Daniel C. Brennan, Robert J. Stratta, Timothy A. Horwedel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Hospitals Low-Volume Time Factors Tissue and Organ Procurement Adolescent Databases Factual medicine.medical_treatment Kaplan-Meier Estimate 030230 surgery Pancreas transplantation Risk Assessment Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Humans Medicine Treatment Failure Healthcare Disparities Kidney transplantation Proportional Hazards Models Retrospective Studies Transplantation Chi-Square Distribution business.industry Proportional hazards model Process Assessment Health Care Network data Retrospective cohort study Pancreas allograft Middle Aged Allografts medicine.disease Kidney Transplantation Surgery Center volume surgical procedures operative Multivariate Analysis Female 030211 gastroenterology & hepatology Pancreas Transplantation business Hospitals High-Volume |
| Zdroj: | Transplantation. 101:2757-2764 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0000000000001628 |
| Popis: | Successful pancreas transplantation requires surgical expertise and multidisciplinary medical management. The impact of transplant center volume on pancreas allograft survival remains unclear.We examined Organ Procurement and Transplantation Network data on 11 568 simultaneous pancreas-kidney (SPK) and 4308 solitary pancreas (pancreas transplant alone and pancreas after kidney) transplants between 2000 and 2013.Average annual transplant center volume was categorized by tertiles into low, medium, and high volume, respectively, as follows: 1 to 6 (n = 3861), 7 to 13 (n = 3891), and 14 to 34 (n = 3888) for SPK, and 1 to 3 (n = 1417), 4 to 10 (n = 1518), and 11 to 33 (n = 1377) for solitary pancreas transplants. Favorable donor characteristics were seen in low-volume centers. For SPK transplantation, low (adjusted hazard ration [aHR], 1.55, 95% confidence interval [CI], 1.34-1.8) and medium (aHR, 1.24; 95% CI, 1.07-1.44) center volumes were associated with a higher risk of early pancreas graft failure at 3 months. The increased risk associated with low center volume extended to 1, 5, and 10 years. For solitary pancreas transplants, low, but not medium, center volume was associated with a higher risk of early pancreas graft failure at 3 months (aHR, 1.56; 95% CI, 1.232-1.976), and this risk persisted over 10 years. Patients transplanted at high-volume centers had better pancreas survival rates across all categories of the Pancreas Donor Risk Index.On average, low center volume were associated with higher risk for pancreas failure. Future studies should seek to identify care processes that support optimal outcomes after pancreas transplantation irrespective of center volume. |
| Databáze: | OpenAIRE |
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