RELATION OF BLOOD GROUP GENOTYPES TO THERAPEUTIC EFFECTIVENESS OF BONE MARROW TRANSPLANTS FOLLOWING X-IRRADIATION
| Autor: | R. C. Fanguy, B. B. Bailey, J. H. Quisenberry |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Bone marrow transplant
Pathology medicine.medical_specialty Meat Bone marrow transplantation Therapeutic effectiveness Genotype Physiology Biology General Biochemistry Genetics and Molecular Biology Poultry Bone Marrow Transplantation Immunology medicine Animals Transplantation Homologous Irradiation Radiation Injuries Bone Marrow Transplantation Blood type Research Breed Radiation Injuries Experimental medicine.anatomical_structure Blood Group Antigens Bone marrow |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 117 |
| ISSN: | 0037-9727 |
| Popis: | SummaryChicks of known blood group genotype and parentage produced from a partially inbred line of Single Comb White Leghorns were subjected to 1800 r of discontinuous X-irradiation when approximately 21 days of age. Irradiation was administered at the rate of 16.5 r/minute in increments of 300 r interspersed with 40-minute intervals without irradiation. Immediately following irradiation hosts received intravenous injections of bone marrow homogenate obtained from sacrificed donors having various degrees of blood group genotype relationship with the respective hosts. Thirty-day post-irradiation mortality of hosts receiving transplants from donors of a different breed or of the same breed but of incompatible A, B, C and D blood group genotype was essentially the same as the irradiated controls receiving no bone marrow transplants. These groups averaged 7.3% survival as opposed to 66.3% survival for hosts receiving transplants from donors of identical blood type. When donor and host were full-sibs in additi... |
| Databáze: | OpenAIRE |
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