Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China

Autor: Stephen L. Buka, Yaqi Zhang, Xichi Zhang, Xinan Yao, Rong Yang, Jieqiong Zhou, Zezhong Tang, Qiang Fu, Lin Qiu, Hui Mei, Tongzhang Zheng, Aifen Zhou, Jiangxia Cao, Youjie Wang, Yiming Zhang
Rok vydání: 2020
Předmět:
Male
Maternal-fetal vertical transmission
lcsh:Medicine
Prom
Infant
Newborn
Diseases
Cohort Studies
0302 clinical medicine
Pregnancy
030212 general & internal medicine
Pregnancy Complications
Infectious
education.field_of_study
Obstetrics
Pregnancy Outcome
Birth outcome
General Medicine
Premature Birth
Female
medicine.symptom
Coronavirus Infections
Live birth
Research Article
Cohort study
Adult
China
medicine.medical_specialty
Pneumonia
Viral
Population
Betacoronavirus
03 medical and health sciences
medicine
Humans
education
Pandemics
Retrospective Studies
Asphyxia
Cesarean Section
SARS-CoV-2
business.industry
lcsh:R
Infant
Newborn
COVID-19
Infant
Retrospective cohort study
Infant
Low Birth Weight
medicine.disease
Pregnancy Complications
Low birth weight
Logistic Models
business
030217 neurology & neurosurgery
Zdroj: BMC Medicine
BMC Medicine, Vol 18, Iss 1, Pp 1-7 (2020)
ISSN: 1741-7015
DOI: 10.1186/s12916-020-01798-1
Popis: Background The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and the risk of adverse birth outcomes. Method We conducted a retrospective cohort study based on the Maternal and Child Health Information System (MCHIMS) of Wuhan, China. All pregnant women with singleton live birth recorded by the system between January 13 and March 18, 2020, were included. The adverse birth outcomes were preterm birth, low birth weight, neonatal asphyxia, premature rupture of membrane (PROM), and cesarean section delivery. Multivariate logistic regression was used to evaluate the associations between maternal COVID-19 diagnosis and adverse birth outcomes. Results Out of 11,078 pregnant women, 65 were confirmed with coronavirus disease 2019 (COVID-19). No deaths occurred from these confirmed cases or their newborns. Compared to pregnant women without COVID-19, pregnant women with a confirmed COVID-19 diagnosis had an increased risk of preterm birth (OR 3.34, 95% CI 1.60–7.00) and cesarean section (OR 3.63, 95% CI 1.95–6.76). There was no statistical difference in low birth weight, neonatal asphyxia, and PROM between the mothers with and without COVID-19. Among these newborns that were born to mothers with confirmed COVID-19, none was tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive or had abnormal CT results. Only one had diarrhea and three had a fever. Conclusions This population-based cohort study suggests that COVID-19 during the later pregnancy is associated with an increased risk of adverse birth outcomes, including iatrogenic preterm birth and cesarean section delivery. Our data provide little evidence for maternal-fetal vertical transmission of SARS-CoV-2. It is important to monitor the long-term health effects of SARS-CoV-2 infection on pregnant women and their children.
Databáze: OpenAIRE
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