The Management and Outcome of Patients with Germ-cell Tumours Treated in the Edinburgh Cancer Centre Between 1988 and 2002
| Autor: | T. B. Hargreave, W. Walker, Duncan McLaren, David N. Tulloch, S. Peoples, G.C.W. Howard, Gillian R. Kerr, D.S. Conkey |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Disease-Free Survival Testicular Neoplasms Risk Factors Internal medicine Cancer centre Humans Medicine Combined Modality Therapy Radiology Nuclear Medicine and imaging Stage (cooking) Survival rate Testicular cancer Aged Neoplasm Staging Retrospective Studies business.industry Retrospective cohort study Seminoma Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease Surgery Survival Rate Treatment Outcome medicine.anatomical_structure business Germ cell |
| Zdroj: | Clinical Oncology. 17:435-440 |
| ISSN: | 0936-6555 |
| Popis: | Aims The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts. Materials and methods Patients referred with gonadal and extra-gonadal primary germ-cell tumours, between 1988 and 2002, were identified from the departmental database, and survival by stage and prognostic group was analysed. Results and conclusions The proportion of patients with stage I seminoma has significantly increased. The good prognosis of patients with early stage disease is confirmed, with the outcome for some groups of patients being better than expected. There is a non-significant trend to improved results over the three 5-year cohorts. The outcome for patients with stage IV seminoma is worse than would be expected, but numbers are small. The poor prognosis of patients with non-seminomatous germ-cell tumours who fall into the International Germ Cell Consensus Classification (IGCCC) poor-prognostic group is confirmed. Failure of patients with metastatic non-seminomatous germ-cell tumours to achieve a complete response to initial therapy is shown to be a poor prognostic indicator. |
| Databáze: | OpenAIRE |
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