Modafinil for excessive daytime sleepiness in myotonic dystrophy
| Autor: | M S Damian, H Reichmann, E Lehmann, F Schmidt, A Gerlach |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Sleep Wake Disorders Multiple Sleep Latency Test Excessive daytime sleepiness Modafinil Myotonic dystrophy Excessive daytime somnolence mental disorders Reaction Time medicine Humans Myotonic Dystrophy Benzhydryl Compounds Sleep disorder medicine.diagnostic_test business.industry Epworth Sleepiness Scale Middle Aged medicine.disease Obstructive sleep apnea Anesthesia Central Nervous System Stimulants Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Neurology. 56:794-796 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | The authors conducted an open-label trial of modafinil for excessive daytime sleepiness in myotonic dystrophy. Eleven patients were evaluated: two were not treated because of obstructive sleep apnea, and nine received 200 to 400 mg modafinil/day for an average of 16.4 weeks. There were no major side effects. Average sleep latency as measured by the Multiple Sleep Latency Test increased from 7.3 to 22.7 minutes ( p = 0.00013), and average Epworth Sleepiness Scale score decreased from 13.25 to 7.75 (p = 0.01028). Modafinil shows evidence of effectiveness for excessive daytime somnolence in myotonic dystrophy and should be investigated further. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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