Cannabinoid Transmission in the Hippocampus Activates Nucleus Accumbens Neurons and Modulates Reward and Aversion-Related Emotional Salience
| Autor: | Steven R. Laviolette, Justine Renard, Cecilia Kramar, Michael Loureiro, Laura G. Rosen |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cannabinoid receptor Microinjections Morpholines media_common.quotation_subject medicine.medical_treatment Emotions Naphthalenes Nucleus accumbens Hippocampal formation Hippocampus Receptors N-Methyl-D-Aspartate Nucleus Accumbens 03 medical and health sciences Glutamatergic Cognition 0302 clinical medicine Piperidines Receptor Cannabinoid CB1 Reward Memory Quinoxalines Conditioning Psychological Avoidance Learning medicine Animals Premovement neuronal activity Receptors AMPA Social Behavior Biological Psychiatry media_common Neurons Addiction Glutamate receptor Benzoxazines Rats 030104 developmental biology Pyrazoles Cannabinoid Dizocilpine Maleate Rimonabant Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Biological Psychiatry. 80:216-225 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2015.10.016 |
| Popis: | Background Cannabinoid receptor transmission strongly influences emotional processing, and disturbances in cannabinoid signaling are associated with various neuropsychiatric disorders. The mammalian ventral hippocampus (vHipp) is a critical neural region controlling mesolimbic activity via glutamatergic projections to the nucleus accumbens. Furthermore, vHipp abnormalities are linked to schizophrenia-related psychopathology. Nevertheless, the mechanisms by which intra-vHipp cannabinoid signaling may modulate mesolimbic activity states and emotional processing are not currently understood. Methods Using an integrative combination of in vivo electrophysiological recordings and behavioral pharmacologic assays in rats, we tested whether activation of cannabinoid type 1 receptors (CB 1 R) in the vHipp may modulate neuronal activity in the shell subregion of the nucleus accumbens (NASh). We next examined how vHipp CB 1 R signaling may control the salience of rewarding or aversive emotional memory formation and social interaction/recognition behaviors via intra-NASh glutamatergic transmission. Results We demonstrate for the first time that vHipp CB 1 R transmission can potently modulate NASh neuronal activity and can differentially control the formation of context-dependent and context-independent forms of rewarding or aversion-related emotional associative memories. In addition, we found that activation of vHipp CB 1 R transmission strongly disrupts normal social behavior and cognition. Finally, we report that these behavioral effects are dependent upon intra-NASh alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid/ N -methyl-D-aspartate receptor transmission. Conclusions Together, these findings demonstrate a critical role for hippocampal cannabinoid signaling in the modulation of mesolimbic neuronal activity states and suggest that dysregulation of CB 1 R transmission in the vHipp→NASh circuit may underlie hippocampal-mediated affective and social behavioral disturbances present in neuropsychiatric disorders. |
| Databáze: | OpenAIRE |
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