Delayed diagnosis of coeliac disease increases cancer risk
| Autor: | Silano, Marco, Volta, Umberto, Mecchia, Anna, Dessì, Mariarita, Di Benedetto, Rita, De Vincenzi, Massimo, Gasbarrini, G., De Vitis, D., Greco, L., Auricchio, S., Santini, D., Scaggiante, F., Federici, M. D., Castellano, E., Sategna-Guidetti, Null, Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Amici, Monica, De Franceschi, L., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., Ferrari, A. |
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| Přispěvatelé: | Silano, Marco, Volta, Umberto, Mecchia, Anna, Dessì, Mariarita, Di Benedetto, Rita, De Vincenzi, Massimo, Gasbarrini, G., De Vitis, D., Greco, Luigi, Auricchio, Salvatore, Santini, D., Scaggiante, F., Federici, M. D., Castellano, E., Sategna Guidetti, Null, Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Amici, Monica, De Franceschi, L., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., Ferrari, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Registrie
tumors Adult Male Risk medicine.medical_specialty Time Factors Time Factor Delayed diagnosis Gastroenterology Coeliac disease Internal medicine Neoplasms medicine Neoplasm Humans Age Factor In patient Registries lcsh:RC799-869 Coeliac disease neoplasm tumors Age Factors Celiac Disease Female Middle Aged business.industry Medicine (all) Settore BIO/12 Cancer General Medicine Hepatology medicine.disease Population study lcsh:Diseases of the digestive system. Gastroenterology Cancer risk business neoplasm Human Research Article |
| Zdroj: | BMC Gastroenterology, Vol 7, Iss 1, p 8 (2007) BMC Gastroenterology |
| Popis: | Background The association between coeliac disease (CD) and neoplasms has been long established, but few data are available about the risk factors. The aim of this paper is to estimate the risk of developing a neoplasm among non diagnosed coeliac patients and to evaluate if this risk correlates with the age of patients at diagnosis of coeliac disease. Methods The study population consists of patients (n = 1968) diagnosed with CD at 20 Italian gastroenterology referral Centers between 1st January 1982 and 31st March 2005. Results The SIR for all cancers resulted to be 1.3; 95% CI = 1.0–1.7 p < 0.001. The specific SIRs for non Hodgkin lymphoma was 4.7; 95% CI = 2.9–7.3 p < 0.001, for the small bowel carcinoma 25; 95% CI = 8.5–51.4 p < 0.001, for non Hodgkin lymphoma 10; 95% CI = 2.7–25 p = 0.01, finally for the stomach carcinoma 3; 95% CI = 1.3–4.9 p < 0.08. The mean age at diagnosis of CD of patients that developed sooner or later a neoplasm was 47,6 ± 10.2 years versus 28.6 ± 18.2 years of patients who did not. Conclusion Coeliac patients have an increased risk of developing cancer in relation to the age of diagnosis of CD. This risk results higher for malignancies of the gastro-intestinal sites. An accurate screening for tumors should be performed in patients diagnosed with CD in adulthood and in advancing age. |
| Databáze: | OpenAIRE |
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