Regional cerebral blood flow and cellular environment in subarachnoid hemorrhage: A thermal doppler flowmetry and microdialysis study
| Autor: | Konstantinos Paterakis, A. Komnos, G Vretzakis, Kostas N. Fountas, G. Krommidas, DC Papadopoulos, Aristotelis S. Filippidis |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Microdialysis Subarachnoid hemorrhage Adolescent Metabolite Clinical correlation 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Doppler flowmetry Internal medicine Glycerol Laser-Doppler Flowmetry Medicine Humans Aged Retrospective Studies business.industry Thermal Conductivity Middle Aged Subarachnoid Hemorrhage medicine.disease Cell stress 030104 developmental biology Endocrinology Cerebral blood flow chemistry Anesthesia Cerebrovascular Circulation Surgery Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neurologia i neurochirurgia polska. 51(1) |
| ISSN: | 0028-3843 |
| Popis: | Background Cerebral microdialysis enables assessment of regional metabolic physiology and provides biomarkers for clinical correlation in critical conditions, such as subarachnoid hemorrhage (SAH). The aim of our current study was to investigate the correlation between regional cerebral blood flow and microdialysis parameters (glucose, lactate, glycerol, pyruvate concentrations, and lactate/pyruvate metabolic ratio) in patients with SAH. Materials and methods Twenty-one patients with SAH were enrolled in our retrospective study. Cerebral blood flow (CBF) based on thermal diffusion methodology, the thermal coefficient K , and microdialysis biochemical markers were recorded. The duration of the brain monitoring was 10 days. Results Microdialysis glucose concentration was inversely related to the cerebral temperature and to the L/P ratio. Furthermore, it was positively correlated to all other microdialysis parameters but glycerol. The K coefficient was strongly and positively correlated with the temperature and marginally with the CBF. The L/P ratio was positively correlated with glycerol, while it was inversely correlated with the CBF. Patients who died had elevated L/P ratio and K coefficient compared to the survivors in our series. Conclusions Thermal conductivity coefficient may change over time as cerebral injury progresses and tissue properties alter. These alterations were found to be associated with the microdialysis metabolite concentrations and the CBF itself. The microdialysis biochemical indices of cell stress and death (glycerol, L/P ratio) were positively related to each other, while the measured L/P metabolic ratio was higher among patients who died. |
| Databáze: | OpenAIRE |
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