A novel glucokinase gene mutation and its effect on glycemic/C-peptide fluctuations in a patient with maturity-onset diabetes of the young type 2

Autor:	Andrew A. Bremer, Lindsey A. Loomba-Albrecht, Maryam Jame
Rok vydání:	2010
Předmět:	Blood Glucose Male medicine.medical_specialty Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Gene mutation Maturity onset diabetes of the young chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Glucokinase Internal Medicine medicine Humans Hypoglycemic Agents Genetic Predisposition to Disease Glycemic C-Peptide business.industry C-peptide Insulin General Medicine Glucose Tolerance Test medicine.disease Sulfonylurea Sulfonylurea Compounds Diabetes Mellitus Type 2 chemistry Area Under Curve Child Preschool Mutation business
Zdroj:	Diabetes Research and Clinical Practice. 87:e23-e25
ISSN:	0168-8227
DOI:	10.1016/j.diabres.2009.11.013
Popis:	Maturity-onset diabetes of the young (MODY) is a group of disorders accounting for 2–5% of diabetes; MODY2 is caused by inactivating GCK mutations. We report a case of MODY2 caused by a novel GCK mutation and demonstrate differential glycemic/C-peptide responses to treatment with insulin, no medication, and an oral sulfonylurea.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcc8ae39826fae567f27acb2f4d2a64 https://doi.org/10.1016/j.diabres.2009.11.013 Zobrazit plný text záznamu Full Text from ScienceDirect