Prevalence and Distribution of Human Papillomavirus Genotypes Among Women in Kinshasa, The Democratic Republic of the Congo
| Autor: | Ina Benoy, Yves Jacquemyn, Johannes Bogers, Rahma Tozin, Jean-Pierre Van Geertruyden, Alex Baleka Mutombo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Cancer Research Genotyping Techniques Uterine Cervical Neoplasms Distribution (economics) lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Viral genetics Genotype Prevalence medicine Humans Mass Screening Original Report Human papillomavirus Papillomaviridae Mass screening Aged 030304 developmental biology Aged 80 and over 0303 health sciences business.industry Papillomavirus Infections Age Factors Cancer Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Virology Oncology 030220 oncology & carcinogenesis DNA Viral Democratic Republic of the Congo Female Human medicine business |
| Zdroj: | Journal of Global Oncology Journal of Global Oncology, Vol 5, Pp 1-9 (2019) |
| ISSN: | 2378-9506 |
| DOI: | 10.1200/jgo.19.00110 |
| Popis: | PURPOSE Cervical cancer is the leading cause of mortality by cancer in sub-Saharan Africa. The human papillomavirus (HPV) infection is recognized as a necessary and sufficient cause for cervical cancer. Population-specific estimates of HPV prevalence in the Democratic Republic of the Congo (DRC) are unknown. This study aims to estimate the prevalence of HPV and identify predominant genotypes circulating in Kinshasa, DRC. METHODS Between July 2015 and July 2017, women were invited to attend a screening program at Mont-Amba Health Centre in Kinshasa. Cervical specimens were collected using the Preservcyt medium. HPV DNA testing was performed for all specimens using real-time polymerase chain reaction. RESULTS During the 2-year period, a total of 1,870 women age 25 to 82 years were screened. The mean age was 46 years (± 11.4 years). The overall HPV prevalence was 28.2% (95% CI, 26.1% to 30.3%). High-risk HPV prevalence was 24.8% (95% CI, 22.8% to 26.8%). Women younger than 30 years had the highest overall HPV prevalence (42.2%; 95% CI, 34.7% to 49.9%). A second peak of prevalence was observed in women age 60 years and older. HPV68 (5.5%; 95% CI, 4.5% to 6.6%) was the most prevalent HPV type. CONCLUSION The distribution of HPV genotypes among women in our population was different compared with other world regions. A key finding was that HPV68 was the most prevalent high-risk HPV genotype. These findings highlight the need for the determination in our population of the etiologic fraction of different HPV types in invasive cervical cancers. |
| Databáze: | OpenAIRE |
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