HLA antigens and infertility with sperm autoantibodies in man
| Autor: | P. Moncharmont, L. Gebuhrer, A. Saad, J. Silou, J. C. Czyba, H. Betuel, J. Rollet, S. Bielsa |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Infertility medicine.medical_specialty Immunology Population Semen Human leukocyte antigen Biology Biochemistry Male infertility Antigen HLA Antigens Internal medicine Genetics medicine Humans Immunology and Allergy education Infertility Male Autoantibodies education.field_of_study Histocompatibility Antigens Class I Histocompatibility Antigens Class II Autoantibody General Medicine medicine.disease Spermatozoa Sperm Endocrinology |
| Zdroj: | Tissue Antigens. 34:90-96 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1989.tb01721.x |
| Popis: | Vasectomized men with sperm auto-antibodies (S.A.A.) and high frequency of HLA-A20 antigen (Ag) were observed by Law et al. (1979); Hancock et al. (1983) observed the prevalence of HLA-A28 in infertile men with S.A.A. HLA-A, B and DR Ag were determined in a population of 80 Caucasian infertile men with (n = 22) or without (n = 58) agglutinating and/or cytotoxic S.A.A. in serum (S) and/or seminal plasma (SP), and the association between HLA-determinants and infertility with S.A.A. was investigated. The frequence of HLA-A28 Ag was found higher in the group with S.A.A. than without (18.2% vs 0.0%) but not statistically significant (chi 2 = 8.87; pc less than 0.15). The same result was obtained with HLA-B13 Ag (chi 2 = 8.87; pc less than 0.32). Lastly, there was no prevalence of HLA-DR Ag in men with S.A.A. In conclusion, no association was found between HLA-A, B and DR Ag and infertility with S.A.A. Nevertheless, two HLA-Ag were more frequently observed in the group with S.A.A. |
| Databáze: | OpenAIRE |
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