Predictors of favorable survival after secondary cytoreductive surgery for recurrent endometrial cancer
| Autor: | Azusa Akiyama, Keiko Nishida, Yoshihiko Hosokawa, Ayumi Shikama, Hiroyuki Ochi, Nobutaka Tasaka, Takeo Minaguchi, Wataru Takao, Toyomi Satoh, Manabu Sakurai |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Adult medicine.medical_specialty Multivariate analysis Disease 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine medicine Humans Aged Retrospective Studies Aged 80 and over Ovarian Neoplasms Performance status business.industry Medical record Histology Hematology General Medicine Cytoreduction Surgical Procedures Middle Aged Prognosis Recurrent Endometrial Cancer Cystadenocarcinoma Serous Endometrial Neoplasms Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis Surgery Female Neoplasm Recurrence Local Cytoreductive surgery business Adenocarcinoma Clear Cell |
| Zdroj: | International journal of clinical oncology. 24(10) |
| ISSN: | 1437-7772 |
| Popis: | The selection criteria for secondary cytoreductive surgery (SCS) for recurrent endometrial cancer (EC) remain to be defined. The present study aimed to identify predictors for favorable survival after SCS for the disease. We retrospectively reviewed the medical records of 112 patients who relapsed by 2016 among 1052 who were diagnosed with primary EC between 1985 and 2014. Characteristics associated with overall survival (OS) after SCS were identified using univariate and multivariate analyses. Twenty-nine of the 112 patients who relapsed underwent SCS. Complete resection was achieved in 18 (62%) patients, whose OS after SCS was significantly better than that of patients receiving incomplete resection (68 vs. 20 months; p = 0.001). Endometrioid histology and performance status (PS) 0 were significant and independent factors for a favorable OS (p = 0.005, and 0.049). The OS of patients with both factors was better than patients with one or no factors (median 75, 19 and 4 months; p = 0.001 and 0.00001). The number of predictors was associated with the rate of complete resection (p = 0.001). Patients with endometrioid histology and PS 0 should be offered SCS for recurrent EC. Prospective trials are warranted to verify this proposal. |
| Databáze: | OpenAIRE |
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