Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression
| Autor: | Piotr Dziegiel, Aleksandra Ambicka, Janusz Rys, Tomasz Owczarek, Alicja M. Kmiecik, Anna Kruczak, Marzena Podhorska-Okolow, Jaroslaw Suchanski, Agnieszka Gomulkiewicz, Bartosz Pula, Maciej Ugorski, Mateusz Olbromski |
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| Rok vydání: | 2014 |
| Předmět: |
Carcinogenesis
Science Cell Mice Nude Nerve Tissue Proteins Triple Negative Breast Neoplasms Biology medicine.disease_cause Prostate cancer Breast cancer Cell Line Tumor medicine Animals Humans Neoplasm Invasiveness Triple-negative breast cancer Cell Proliferation Multidisciplinary Tissue Inhibitor of Metalloproteinase-1 Cell growth Middle Aged medicine.disease Survival Analysis Metallothionein 3 medicine.anatomical_structure Cancer cell Cancer research Medicine Female Matrix Metalloproteinase 3 Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 5, p e0124865 (2015) |
| ISSN: | 1932-6203 |
| Popis: | It has been recently found that metallothionein-3 (MT3) enhances the invasiveness and tumorigenesis of prostate cancer cells. This finding is in contrast to those of earlier studies, which indicated that overexpression of MT3 in breast cancer and prostate cancer cell lines inhibits their growth in vitro. Therefore, to clarify the role of MT3 in breast cancer progression, we analyzed the effect of MT3-overexpression on proliferation, invasiveness, migration, and tumorigenesis of breast cancer MDA-MB-231/BO2 cells. It was found that MDA-MB-231/BO2 cells overexpressing MT3 were characterized by increased invasiveness in vitro, compared to the control cells. Interestingly, this increased invasiveness correlated with a highly increased concentration of MMP3 in the culture supernatants (p |
| Databáze: | OpenAIRE |
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