Mucoepidermoid Carcinoma of the Lacrimal Sac: Clinical-Pathologic Analysis, Including Molecular Genetics
| Autor: | Mary A. Stefanyszyn, Robert B. Penne, Paul J. Zhang, Tatyana Milman, Kalla A Gervasio, Raghunath Puthiyaveettil, Ralph C. Eagle |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Adenosquamous carcinoma medicine.disease Lacrimal sac stomatognathic diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Tumor morphology Mucoepidermoid carcinoma 030220 oncology & carcinogenesis Molecular genetics 030221 ophthalmology & optometry medicine Immunohistochemistry Salivary Gland Mucoepidermoid Carcinoma business General Nursing Research Article Fluorescence in situ hybridization |
| Zdroj: | Ocul Oncol Pathol |
| ISSN: | 2296-4657 2296-4681 |
| DOI: | 10.1159/000502699 |
| Popis: | Purpose: The aim of this study was to assess whether mucoepidermoid carcinoma of the lacrimal sac is a counterpart of CRTC1/3-MAML2 gene fusion-related salivary gland mucoepidermoid carcinoma. Methods: In this retrospective observational case series, pathology records were searched for all cases of lacrimal sac mucoepidermoid carcinoma diagnosed between 1990 and 2018. Data collected included demographics, clinical findings, management, and follow-up. Pathologic parameters assessed included tumor morphology, immunohistochemistry, and MAML2 and EGFR fluorescence in situ hybridization (FISH) studies. Results: Six patients with mucoepidermoid carcinoma of the lacrimal sac, 5 males and 1 female, with a median age of 63 years (range 24–66) were identified. Five tumors were managed with radical resection and 1 patient underwent orbital exenteration. None of the patients developed recurrence or metastases with an average follow-up of 18 months (range 13–23). All tumors had morphologic and immunohistochemical features of mucoepidermoid carcinoma and overexpressed EGFR. MAML2 FISH was negative for MAML2 rearrangement in all tumors. EGFR FISH demonstrated EGFR amplification in 1 tumor. Conclusions: Mucoepidermoid carcinoma of the lacrimal sac is not a lacrimal sac counterpart of CRTC1/3-MAML2 gene fusion-related salivary gland mucoepidermoid carcinoma. EGFR pathway activation and EGFR amplification in a subset of these neoplasms suggest the potential role for anti-EGFR agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|