Reperfusion with ATP-MgCl2 following prolonged ischemia improves myocardial performance
| Autor: | Arthur E. Baue, Spyros G. Condos, Gary S. Kopf, Irshad H. Chaudry |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Cardiac function curve
Ischemia Hemodynamics Coronary Disease law.invention Adenosine Triphosphate Dogs law Heart rate medicine Cardiopulmonary bypass Animals Cardiac Output biology business.industry Fissipedia Heart Hypothermia biology.organism_classification medicine.disease Perfusion Anesthesia Surgery medicine.symptom business Reperfusion injury |
| Zdroj: | The Journal of surgical research. 43(2) |
| ISSN: | 0022-4804 |
| Popis: | This study was designed to test the hypothesis that infusion of ATP-MgCl2 during reperfusion following a prolonged period of hypothermic global ischemia would result in enhanced functional recovery of cardiac function. Two groups of dogs (n = 6 each) were placed on cardiopulmonary bypass (CP) with systemic hypothermia to 28 degrees C and subjected to 150 min of aortic cross-clamping. Crystalloid cardioplegia was infused every 20 min during ischemia. Reperfusion and rewarming were carried out for 20 min before discontinuation of CP bypass. During reperfusion, the experimental group received ATP-MgCl2(1.0 mg/kg/min ATP, 0.33 mg/kg/min magnesium). At 15 and 45 min following bypass, hemodynamic assessment was carried out for each animal by constructing Starling curves over a range of filling pressures at constant heart rate and comparing each animal to its own prebypass control level. The results indicated that ATP-treated animals exhibited complete functional recovery whereas control animals showed marked reduction in hemodynamic performance and myocardial compliance and had a higher myocardial water content (P less than 0.05). We conclude that infusion of ATP-MgCl2 during reperfusion following hypothermic ischemia may help ameliorate reperfusion injury. |
| Databáze: | OpenAIRE |
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