Enterobacterial infection modulates major histocompatibility complex class I expression on mononuclear cells
| Autor: | Mäki-Ikola O, M Wuorela, Granfors K, Putto-Laurila A, Juha Kirveskari, Marjatta Leirisalo-Repo, Qiushui He |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Salmonella typhimurium musculoskeletal diseases Adolescent Yersinia Infections Immunology Cell CD1 Down-Regulation Yersinia Major histocompatibility complex Arthritis Reactive Peripheral blood mononuclear cell Monocytes HLA-A2 Antigen Prohibitins Genotype MHC class I medicine Humans Immunology and Allergy Reactive arthritis HLA-B27 Antigen Yersinia enterocolitica biology Histocompatibility Antigens Class I Enterobacteriaceae Infections Original Articles Middle Aged biology.organism_classification medicine.disease Klebsiella Infections medicine.anatomical_structure Antigens Surface Salmonella Infections Leukocytes Mononuclear biology.protein Female Follow-Up Studies |
| Zdroj: | Immunology. 97:420-428 |
| ISSN: | 1365-2567 0019-2805 |
| DOI: | 10.1046/j.1365-2567.1999.00803.x |
| Popis: | Major histocompatibility complex (MHC) class I expression is reduced in several viral infections, but it is not known whether the same happens during infections caused by intracellular enterobacteria. In this study, the expression of MHC class I antigens on peripheral blood mononuclear cells (PBMC) from 16 patients with Salmonella, Yersinia, or Klebsiella infection was investigated. During or after the acute infection, the expression of MHC class I antigens was markedly decreased in eight patients, all with genotype HLA-B27, and six out of eight with reactive arthritis (ReA). A significant decrease of monomorphic MHC class I was found in three patients, of HLA-B27 in eight (P < 0·05) and of HLA-A2 in two. However, patients negative for the HLA-B27 genotype, or healthy HLA-B27-positive individuals, did not have a significant decrease of MHC class I antigens. During the decreased expression on the cell surface, intracellular retention of MHC class I antigens was observed, whereas HLA-B27 mRNA levels did not vary significantly. This is the first evidence that enterobacterial infection may down-regulate expression of MHC class I molecules in vivo and that down-regulation is predominant in patients with the HLA-B27 genotype. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|