Flash forward genetics: new twists in transcription across evolutionary boundaries
| Autor: | G. Paolo Dotto, Caterina Missero |
|---|---|
| Přispěvatelé: | Dotto, G. P., Missero, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Mice
Nude Computational biology Biology Biochemistry 03 medical and health sciences Mice 0302 clinical medicine Genetics medicine Molecular Biology Transcription factor 030304 developmental biology Regulation of gene expression 0303 health sciences integumentary system Animal Forkhead Transcription Factor Hair follicle Biological Evolution Forward genetics Hair follicle morphogenesis medicine.anatomical_structure Gene Expression Regulation Transcription (software) Hair Follicle 030217 neurology & neurosurgery Function (biology) Genetic screen |
| Popis: | "Flash forward genetics" refers to a genetic approach based on the functional interaction of a given factor with unknown partner(s) converging on shared targets across evolutionary boundaries. A study by Li et al (2021), published in this issue of EMBO Reports, illustrates the innovative potential of the approach. The authors applied it to identify interacting factors for FOXN1, a mammalian transcription factor with a highly specialized function in hair follicle morphogenesis and thymus. The authors express FOXN1 in the Drosophila eye to perform an unbiased genetic screen in a totally heterologous system. In a remarkable tour de force, the authors identify and characterize a factor so far known for its ubiquitous function in transcription elongation, AFF4. Li et al show that AFF4 plays also a specific role in hair follicle and thymus development in the mouse overlapping with that of FOXN1. |
| Databáze: | OpenAIRE |
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