Systemic liberation of interleukin-8 in the perioperative phase of liver transplantation
| Autor: | Jörg C. Gerlach, Axel Berger, Roland Nohr, Michael R. Schön, Achim Jörres, Peter Neuhaus, Mark A. Smith, Gabriele Spatkowski |
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| Rok vydání: | 1997 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty medicine.medical_treatment Graft vs Host Disease Liver transplantation Cold Ischemia Time Tacrolimus Internal medicine medicine Humans Interleukin 8 Postoperative Period Liver preservation Transplantation business.industry Interleukin-8 Perioperative Middle Aged Surgery Liver Transplantation Cytokine Liver Anesthesia Cyclosporine Female business Immunosuppressive Agents |
| Zdroj: | Transplant International. 10:401-404 |
| ISSN: | 1432-2277 0934-0874 |
| Popis: | Serum levels of interleukin-8 (IL-8) were investigated in the perioperative phase of liver transplantation (LTx) in order to help determine whether this cytokine might serve as a parameter for preservation injury. In a study of 45 patients undergoing LTx, systemic IL-8 was estimated at the end of the anhepatic phase, at 30, 60, and 120 min after reperfusion of the graft, and 24 h and 7 days after LTx. A maximum mean concentration of 665 +/- 135 pg/ml was seen 60 min after LTx. The minimum was found on the 1st postoperative day (POD 1): 328 +/- 33 pg/ml. Significant changes were found between 60 min and PODs 1 and 7, as well as between 120 min and POD 1. Differences in cold ischemia time were not found to be significant. We conclude that monitoring of systemic IL-8 levels is not useful in the development of new liver preservation concepts. |
| Databáze: | OpenAIRE |
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