ABNORMALITIES IN SKELETAL GROWTH IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
| Autor: | Laura S. Hillman, James T. Cassidy |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Bone density Bone disease Appendicular skeleton Arthritis Rheumatology Bone Density Internal medicine medicine Humans Child Accelerated skeletal maturation Juvenile osteoporosis Growth Disorders Bone Development business.industry medicine.disease Arthritis Juvenile medicine.anatomical_structure Endocrinology Child Preschool Rheumatoid arthritis Osteoporosis Female business Juvenile rheumatoid arthritis |
| Zdroj: | Rheumatic Disease Clinics of North America. 23:499-522 |
| ISSN: | 0889-857X |
| DOI: | 10.1016/s0889-857x(05)70345-8 |
| Popis: | A review of the acquisition of peak skeletal mass in normal children and studies that have been reported for children with JRA lead to the following tentative conclusions: (1) The appendicular skeleton is predominantly the overall status of skeletal mineralization; (2) a failure to develop adequate bone mineralization is virtually universal in children with JRA and is characterized by a failure of bone formation. A failure to undergo the normal increase in bone mass during puberty is common in children with JRA and markedly decreases their potential to achieve an adequate peak skeletal mass; (3) the onset of accelerated skeletal maturation with puberty is a critical period of potential intervention in JRA. Conversely, therapeutic interventions later during adolescence offer less promise of reversal of inadequate bone mineralization; and (4) the most important therapeutic maneuver is likely to be control of the inflammation process, although there is hope, at present unsubstantiated, that supplemental dietary calcium and vitamin D, and normalization of physical activity, many lead to some "catch-up" mineralization. |
| Databáze: | OpenAIRE |
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